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Novel Drug Delivery Systems, Second Edition, (Drugs and the Pharmaceutical Sciences) books pdf file




If you are interested in learning more about the science, technology, and regulation of rate-controlled administration of therapeutic agents, you might want to read this book. Novel Drug Delivery Systems, Second Edition, is a comprehensive treatment of the basic concepts, fundamental principles, biomedical rationales, and potential applications of novel drug delivery systems. In this article, we will give you an overview of what novel drug delivery systems are, what the book is about, how to get the book in pdf format, and some frequently asked questions.




Novel Drug Delivery Systems, Second Edition, (Drugs and the Pharmaceutical Sciences) books pdf file



What are novel drug delivery systems?




Novel drug delivery systems are methods or devices that can deliver drugs to specific sites in the body or control the release rate or duration of drugs in the body. They aim to improve the efficacy, safety, convenience, and compliance of drug therapy. There are different types of novel drug delivery systems, such as:



  • Nano-based drug delivery systems: These use nanoscale materials or structures to deliver drugs across biological barriers or target specific cells or tissues.



  • Targeted drug delivery systems: These use various strategies or mechanisms to direct drugs to specific organs or cells or receptors.



  • Controlled-release drug delivery systems: These use various techniques or materials to modulate the release rate or duration of drugs in the body.



  • Mucoadhesive drug delivery systems: These use adhesive properties of polymers or other materials to attach drugs to mucosal surfaces for prolonged contact time.



  • Transdermal drug delivery systems: These use skin as a route of administration for drugs that can penetrate the skin barrier or enhance skin permeability.



  • Pulmonary drug delivery systems: These use inhalation as a route of administration for drugs that can reach the lungs or systemic circulation through the respiratory tract.



  • Ocular drug delivery systems: These use eye drops, gels, inserts, implants, or nanoparticles to deliver drugs to the eye or treat ocular diseases.



  • Nasal drug delivery systems: These use nasal sprays, drops, gels, powders, or nanoparticles to deliver drugs to the nose or treat nasal diseases.



  • Buccal drug delivery systems: These use tablets, films, patches, lozenges, or gels to deliver drugs to the buccal cavity or treat oral diseases.



  • Vaginal drug delivery systems: These use creams, gels, rings, tablets, capsules, or nanoparticles to deliver drugs to the vagina or treat vaginal diseases.



  • Rectal drug delivery systems: These use suppositories, enemas, gels, foams, or nanoparticles to deliver drugs to the rectum or treat rectal diseases.



Advantages and challenges of novel drug delivery systems




Novel drug delivery systems have many advantages over conventional drug delivery systems, such as:



  • Improved bioavailability: They can enhance the solubility, stability, absorption, distribution, or elimination of drugs in the body.



  • Reduced side effects: They can minimize the exposure of healthy tissues or organs to drugs or reduce the toxicity or adverse reactions of drugs.



  • Enhanced therapeutic efficacy: They can increase the concentration of drugs at the site of action or prolong the duration of action of drugs.



  • Optimized dosing regimen: They can reduce the frequency or amount of drug administration or achieve a constant or desired plasma level of drugs.



  • Improved patient compliance: They can offer more convenient, comfortable, or painless modes of drug administration or delivery.



However, novel drug delivery systems also face many challenges, such as:



  • Complex design and development: They require sophisticated materials, techniques, equipment, and expertise to design and develop novel drug delivery systems.



  • High cost and risk: They involve high investment, time, and risk in the research and development, manufacturing, and marketing of novel drug delivery systems.



  • Regulatory hurdles and ethical issues: They have to meet stringent standards and regulations for the safety, quality, efficacy, and bioequivalence of novel drug delivery systems. They also have to address ethical issues such as informed consent, privacy, or social justice.



What is the book about?




The book Novel Drug Delivery Systems, Second Edition, is a comprehensive treatment of the science, technology, and regulation of rate-controlled administration of therapeutic agents. It was written by Yie Chien, a professor of pharmaceutics at Rutgers University. It was published by Taylor & Francis in 1991 as part of the Drugs and the Pharmaceutical Sciences series. It has 816 pages and 6 reviews on Google Books.


Author and background of the book




Yie Chien is a professor of pharmaceutics at Rutgers University. He received his B.S. in pharmacy from National Taiwan University in 1961, his M.S. in pharmaceutics from University of Wisconsin in 1964, and his Ph.D. in pharmaceutics from University of Michigan in 1968. He has been teaching and researching at Rutgers University since 1970. He has published over 200 papers and 10 books on various topics related to drug delivery systems. He is also a fellow of the American Association of Pharmaceutical Scientists and the Controlled Release Society.


The book Novel Drug Delivery Systems, Second Edition, is a revised and updated edition of the first edition published in 1982. It incorporates new developments and advances in the field of novel drug delivery systems that occurred in the 1980s. It also covers new topics such as transdermal drug delivery systems, pulmonary drug delivery systems, ocular drug delivery systems, nasal drug delivery systems, buccal drug delivery systems, vaginal drug delivery systems, rectal drug delivery systems, and biodegradable polymers.


Summary and main topics of the book




The book Novel Drug Delivery Systems, Second Edition, is divided into four parts: Part I: Basic Concepts; Part II: Fundamental Principles; Part III: Biomedical Rationales; Part IV: Potential Applications. The book covers the following main topics:



Part


Topics


I


- Introduction to novel drug delivery systems- Physicochemical principles of drug release- Pharmacokinetic principles of drug release- Pharmacodynamic principles of drug release- Regulatory principles of drug release


II


- Diffusion-controlled drug release- Dissolution-controlled drug release- Osmotic-controlled drug release- Ion-exchange-controlled drug release- Hydrolysis-controlled drug release- Erosion-controlled drug release- Bioerosion-controlled drug release- Bioadhesion-controlled drug release- Temperature-controlled drug release- Electrically-controlled drug release- Magnetically-controlled drug release- Ultrasound-controlled drug release- Enzyme-controlled drug release- pH-controlled drug release


III


Controlled-release vaginal dosage forms




Controlled-release vaginal dosage forms are designed to deliver drugs to the vagina or the systemic circulation for a prolonged period of time. They can be used for various purposes, such as contraception, hormone replacement therapy, prevention or treatment of vaginal infections, or prevention of sexually transmitted infections (STIs), including HIV. Some examples of controlled-release vaginal dosage forms are:



  • Intravaginal rings (IVRs): These are torus-shaped devices that are inserted into the vagina and release one or more drugs over several weeks to months. They can be made of elastomeric or thermoplastic polymers and can have matrix or reservoir designs. They can deliver drugs such as steroids, microbicides, antibodies, or recombinant proteins .



  • Vaginal tablets: These are solid dosage forms that are inserted into the vagina and dissolve or erode over time. They can deliver drugs such as antifungals, antiprotozoals, antivirals, or spermicides .



  • Vaginal capsules: These are gelatinous dosage forms that are inserted into the vagina and release drugs by dissolution or disintegration. They can deliver drugs such as antibiotics, antifungals, antiprotozoals, antivirals, or spermicides .



  • Vaginal films: These are thin, flexible dosage forms that are inserted into the vagina and adhere to the vaginal mucosa. They can deliver drugs such as microbicides, hormones, or spermicides .



  • Vaginal gels: These are semi-solid dosage forms that are applied to the vagina using an applicator or a syringe. They can deliver drugs such as microbicides, hormones, or spermicides .



  • Vaginal implants: These are solid or semi-solid dosage forms that are surgically implanted into the vagina and release drugs over months to years. They can deliver drugs such as steroids, microbicides, or vaccines .



  • Vaginal nanoparticles: These are nanoscale dosage forms that are administered to the vagina using various methods. They can deliver drugs such as microbicides, hormones, antibodies, or recombinant proteins .



The current available dosage forms for vaginal drug delivery have some limitations, such as leakage, messiness, low patient compliance, low retention time, variable absorption, irritation, infection, or drug degradation . Therefore, there is a need for developing novel and improved vaginal drug delivery systems that can overcome these challenges and provide more effective and safe drug delivery.


How to get the book in pdf format?




If you want to get the book Novel Drug Delivery Systems, Second Edition, in pdf format, you have to consider some legal and ethical issues before downloading it from online sources. You also have to know some sources and methods of downloading books in pdf format. Finally, you have to follow some tips and precautions for downloading books in pdf format.


Legal and ethical issues of downloading books in pdf format




Downloading books in pdf format from online sources may involve some legal and ethical issues depending on the source and the copyright status of the book. Some sources may offer free or paid access to books in pdf format legally and ethically. For example:



  • Open access sources: These are sources that provide free and unrestricted access to books in pdf format that are either in the public domain or have been published under open licenses. For example: Project Gutenberg (https://www.gutenberg.org/), Internet Archive (https://archive.org/), Google Books (https://books.google.com/), etc.



  • Paid access sources: These are sources that provide paid access to books in pdf format that have been legally obtained from publishers or authors. For example: Amazon Kindle (https://www.amazon.com/Kindle-eBooks/), Barnes & Noble Nook (https://www.barnesandnoble.com/b/nook-books/), Kobo (https://www.kobo.com/), etc.



However, some sources may offer illegal or unethical access to books in pdf format that violate the intellectual property rights of publishers or authors. For example:



  • Pirated sources: These are sources that provide free or paid access to books in pdf format that have been illegally copied, distributed, or shared without the permission of publishers or authors. For example: Torrent sites, file-sharing sites, peer-to-peer networks, etc.



  • Plagiarized sources: These are sources that provide free or paid access to books in pdf format that have been partially or fully copied, rewritten, or paraphrased from other sources without proper citation or acknowledgment. For example: Essay mills, academic cheating sites, content farms, etc.



Downloading books in pdf format from illegal or unethical sources may have serious consequences, such as:



  • Legal consequences: You may face legal actions, fines, or penalties from publishers or authors for infringing their intellectual property rights. You may also face legal actions, fines, or penalties from authorities for violating the laws or regulations of your country or region.



  • Ethical consequences: You may harm the reputation, income, or livelihood of publishers or authors for depriving them of their rightful rewards. You may also harm the quality, credibility, or integrity of the books for compromising their originality, accuracy, or authenticity.



Therefore, you should always respect the intellectual property rights of publishers or authors and download books in pdf format from legal and ethical sources only.


Sources and methods of downloading books in pdf format




If you want to download the book Novel Drug Delivery Systems, Second Edition, in pdf format from legal and ethical sources, you have to find out if the book is available in pdf format from any of the following sources:



  • The publisher's website: You can check if the publisher of the book (Taylor & Francis) offers the book in pdf format on its website (https://www.taylorfrancis.com/). You may have to pay a fee to access the book in pdf format.



  • The author's website: You can check if the author of the book (Yie Chien) offers the book in pdf format on his website (https://pharmacy.rutgers.edu/directory/yie-chien/). You may have to pay a fee or request a permission to access the book in pdf format.



  • The library's website: You can check if your local or online library offers the book in pdf format on its website. You may have to register as a member or use your library card to access the book in pdf format.



  • The open access sources: You can check if any of the open access sources mentioned above offers the book in pdf format. You can access the book in pdf format for free.



  • The paid access sources: You can check if any of the paid access sources mentioned above offers the book in pdf format. You have to pay a fee to access the book in pdf format.



If you find out that the book is available in pdf format from any of these sources, you can download it by following these steps:



  • Go to the source's website: Use your web browser to go to the website of the source that offers the book in pdf format.



  • Search for the book: Use the search function or browse through the categories to find the book on the website.



  • Select the book: Click on the title or image of the book to go to its page on the website.



  • Select the pdf format: Look for an option or a link that allows you to download or view the book in pdf format. It may be labeled as "PDF", "Download", "Read Online", "Full Text", etc.



Tips and precautions for downloading books in pdf format




If you want to download books in pdf format safely and successfully, you should follow some tips and precautions, such as:



  • Check the source's credibility and reputation: You should only download books in pdf format from sources that are trustworthy and reputable. You can check the source's credibility and reputation by looking at its domain name, design, content, reviews, ratings, feedback, etc.



  • Check the book's quality and authenticity: You should only download books in pdf format that are well-written and original. You can check the book's quality and authenticity by looking at its title, author, publisher, edition, ISBN, cover, summary, preview, etc.



  • Check the file's size and format: You should only download books in pdf format that are compatible with your device and software. You can check the file's size and format by looking at its extension, name, icon, description, etc.



  • Check your device's storage and battery: You should only download books in pdf format when you have enough storage space and battery power on your device. You can check your device's storage and battery by looking at its settings, indicators, notifications, etc.



  • Check your internet connection and speed: You should only download books in pdf format when you have a stable and fast internet connection. You can check your internet connection and speed by looking at your network status, signal strength, speed test, etc.



  • Check your security and privacy settings: You should only download books in pdf format when you have a secure and private browsing environment. You can check your security and privacy settings by looking at your browser options, firewall settings, antivirus software, VPN service, etc.



  • Scan the file for viruses or malware: You should always scan the file for viruses or malware before opening or reading it. You can scan the file for viruses or malware by using your antivirus software, online scanner tools, etc.



Conclusion




In conclusion, Novel Drug Delivery Systems, Second Edition, is a book that covers the science, technology, and regulation of rate-controlled administration of therapeutic agents. It is written by Yie Chien and published by Taylor & Francis in 1991. It is a comprehensive treatment of the basic concepts, fundamental principles, biomedical rationales, and potential applications of novel drug delivery systems. If you want to get the book in pdf format, you have to consider some legal and ethical issues before downloading it from online sources. You also have to know some sources and methods of downloading books in pdf format. Finally, you have to follow some tips and precautions for downloading books in pdf format.


FAQs




Here are some frequently asked questions about Novel Drug Delivery Systems, Second Edition:



  • What is the difference between novel drug delivery systems and conventional drug delivery systems?A: Novel drug delivery systems are methods or devices that can deliver drugs to specific sites in the body or control the release rate or duration of drugs in the body. Conventional drug delivery systems are methods or devices that deliver drugs without any specificity or control over their release.



  • Vaginal drug delivery systems: These use creams, gels, rings, tablets, capsules, or nanoparticles to deliver drugs to the vagina or treat vaginal diseases.



  • Rectal drug delivery systems: These use suppositories, enemas, gels, foams, or nanoparticles to deliver drugs to the rectum or treat rectal diseases.



Controlled-release rectal dosage forms




Controlled-release rectal dosage forms are designed to deliver drugs to the rectum or the systemic circulation for a prolonged period of time. They can be used for various purposes, such as constipation relief, hemorrhoid treatment, pain management, or prevention or treatment of infections. Some examples of controlled-release rectal dosage forms are:



  • Rectal suppositories: These are solid or semi-solid dosage forms that are inserted into the rectum and melt, dissolve, or disintegrate over time. They can deliver drugs such as laxatives, steroids, anesthetics, antipyretics, or antibiotics .



  • Rectal enemas: These are liquid or semi-liquid dosage forms that are administered into the rectum using a syringe or a tube. They can deliver drugs such as laxatives, steroids, anti-inflammatories, antiseptics, or immunomodulators .



Rectal gels: These are


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