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Novel Drug Delivery Systems, Second Edition, (Drugs and the Pharmaceutical Sciences) books pdf file




If you are interested in learning more about the science, technology, and regulation of rate-controlled administration of therapeutic agents, you might want to read this book. Novel Drug Delivery Systems, Second Edition, is a comprehensive treatment of the basic concepts, fundamental principles, biomedical rationales, and potential applications of novel drug delivery systems. In this article, we will give you an overview of what novel drug delivery systems are, what the book is about, how to get the book in pdf format, and some frequently asked questions.




Novel Drug Delivery Systems, Second Edition, (Drugs and the Pharmaceutical Sciences) books pdf file



What are novel drug delivery systems?




Novel drug delivery systems are methods or devices that can deliver drugs to specific sites in the body or control the release rate or duration of drugs in the body. They aim to improve the efficacy, safety, convenience, and compliance of drug therapy. There are different types of novel drug delivery systems, such as:



  • Nano-based drug delivery systems: These use nanoscale materials or structures to deliver drugs across biological barriers or target specific cells or tissues.



  • Targeted drug delivery systems: These use various strategies or mechanisms to direct drugs to specific organs or cells or receptors.



  • Controlled-release drug delivery systems: These use various techniques or materials to modulate the release rate or duration of drugs in the body.



  • Mucoadhesive drug delivery systems: These use adhesive properties of polymers or other materials to attach drugs to mucosal surfaces for prolonged contact time.



  • Transdermal drug delivery systems: These use skin as a route of administration for drugs that can penetrate the skin barrier or enhance skin permeability.



  • Pulmonary drug delivery systems: These use inhalation as a route of administration for drugs that can reach the lungs or systemic circulation through the respiratory tract.



  • Ocular drug delivery systems: These use eye drops, gels, inserts, implants, or nanoparticles to deliver drugs to the eye or treat ocular diseases.



  • Nasal drug delivery systems: These use nasal sprays, drops, gels, powders, or nanoparticles to deliver drugs to the nose or treat nasal diseases.



  • Buccal drug delivery systems: These use tablets, films, patches, lozenges, or gels to deliver drugs to the buccal cavity or treat oral diseases.



  • Vaginal drug delivery systems: These use creams, gels, rings, tablets, capsules, or nanoparticles to deliver drugs to the vagina or treat vaginal diseases.



  • Rectal drug delivery systems: These use suppositories, enemas, gels, foams, or nanoparticles to deliver drugs to the rectum or treat rectal diseases.



Advantages and challenges of novel drug delivery systems




Novel drug delivery systems have many advantages over conventional drug delivery systems, such as:



  • Improved bioavailability: They can enhance the solubility, stability, absorption, distribution, or elimination of drugs in the body.



  • Reduced side effects: They can minimize the exposure of healthy tissues or organs to drugs or reduce the toxicity or adverse reactions of drugs.



  • Enhanced therapeutic efficacy: They can increase the concentration of drugs at the site of action or prolong the duration of action of drugs.



  • Optimized dosing regimen: They can reduce the frequency or amount of drug administration or achieve a constant or desired plasma level of drugs.



  • Improved patient compliance: They can offer more convenient, comfortable, or painless modes of drug administration or delivery.



However, novel drug delivery systems also face many challenges, such as:



  • Complex design and development: They require sophisticated materials, techniques, equipment, and expertise to design and develop novel drug delivery systems.



  • High cost and risk: They involve high investment, time, and risk in the research and development, manufacturing, and marketing of novel drug delivery systems.



  • Regulatory hurdles and ethical issues: They have to meet stringent standards and regulations for the safety, quality, efficacy, and bioequivalence of novel drug delivery systems. They also have to address ethical issues such as informed consent, privacy, or social justice.



What is the book about?




The book Novel Drug Delivery Systems, Second Edition, is a comprehensive treatment of the science, technology, and regulation of rate-controlled administration of therapeutic agents. It was written by Yie Chien, a professor of pharmaceutics at Rutgers University. It was published by Taylor & Francis in 1991 as part of the Drugs and the Pharmaceutical Sciences series. It has 816 pages and 6 reviews on Google Books.


Author and background of the book




Yie Chien is a professor of pharmaceutics at Rutgers University. He received his B.S. in pharmacy from National Taiwan University in 1961, his M.S. in pharmaceutics from University of Wisconsin in 1964, and his Ph.D. in pharmaceutics from University of Michigan in 1968. He has been teaching and researching at Rutgers University since 1970. He has published over 200 papers and 10 books on various topics related to drug delivery systems. He is also a fellow of the American Association of Pharmaceutical Scientists and the Controlled Release Society.


The book Novel Drug Delivery Systems, Second Edition, is a revised and updated edition of the first edition published in 1982. It incorporates new developments and advances in the field of novel drug delivery systems that occurred in the 1980s. It also covers new topics such as transdermal drug delivery systems, pulmonary drug delivery systems, ocular drug delivery systems, nasal drug delivery systems, buccal drug delivery systems, vaginal drug delivery systems, rectal drug delivery systems, and biodegradable polymers.


Summary and main topics of the book




The book Novel Drug Delivery Systems, Second Edition, is divided into four parts: Part I: Basic Concepts; Part II: Fundamental Principles; Part III: Biomedical Rationales; Part IV: Potential Applications. The book covers the following main topics:



Part


Topics


I


- Introduction to novel drug delivery systems- Physicochemical principles of drug release- Pharmacokinetic principles of drug release- Pharmacodynamic principles of drug release- Regulatory principles of drug release


II


- Diffusion-controlled drug release- Dissolution-controlled drug release- Osmotic-controlled drug release- Ion-exchange-controlled drug release- Hydrolysis-controlled drug release- Erosion-controlled drug release- Bioerosion-controlled drug release- Bioadhesion-controlled drug release- Temperature-controlled drug release- Electrically-controlled drug release- Magnetically-controlled drug release- Ultrasound-controlled drug release- Enzyme-controlled drug release- pH-controlled drug release


III


Controlled-release vaginal dosage forms




Controlled-release vaginal dosage forms are designed to deliver drugs to the vagina or the systemic circulation for a prolonged period of time. They can be used for various purposes, such as contraception, hormone replacement therapy, prevention or treatment of vaginal infections, or prevention of sexually transmitted infections (STIs), including HIV. Some examples of controlled-release vaginal dosage forms are:



  • Intravaginal rings (IVRs): These are torus-shaped devices that are inserted into the vagina and release one or more drugs over several weeks to months. They can be made of elastomeric or thermoplastic polymers and can have matrix or reservoir designs. They can deliver drugs such as steroids, microbicides, antibodies, or recombinant proteins .



  • Vaginal tablets: These are solid dosage forms that are inserted into the vagina and dissolve or erode over time. They can deliver drugs such as antifungals, antiprotozoals, antivirals, or spermicides .



  • Vaginal capsules: These are gelatinous dosage forms that are inserted into the vagina and release drugs by dissolution or disintegration. They can deliver drugs such as antibiotics, antifungals, antiprotozoals, antivirals, or spermicides .



  • Vaginal films: These are thin, flexible dosage forms that are inserted into the vagina and adhere to the vaginal mucosa. They can deliver drugs such as microbicides, hormones, or spermicides .



  • Vaginal gels: These are semi-solid dosage forms that are applied to the vagina using an applicator or a syringe. They can deliver drugs such as microbicides, hormones, or spermicides .



  • Vaginal implants: These are solid or semi-solid dosage forms that are surgically implanted into the vagina and release drugs over months to years. They can deliver drugs such as steroids, microbicides, or vaccines .